Nurturing Life Sciences
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#Unit 3. Fundamental Processes
In nonsense mediated decay in the addition of multiple lysines to the end of the protein (AAA is the codon for lysine) and stalling of the ribosome at the end of the mRNA.
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Upf1 is the first NMD protein to act, binding to the terminating ribosome—specifically to its release factor complex.
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nonstop-mediated decay rescues ribosomes that translate mRNAs that lack a stop codon. When an mRNA lacking a stop codon is translated, the ribosome translates through the poly-A tail This results
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