There are three different modes of cell specification: 

1. Autonomous

2. Conditional

3. Syncytial

TLS Online TPP Program

#Id: 2654

#Unit 7. System Physiology – Animal

Thick segment of the ascending limb of loop of Henle, has thick epithelial cells that have high metabolic activity and are capable of active reabsorption of sodium, chloride, and potassium

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#Id: 2655

#Unit 7. System Physiology – Animal

About 25 percent of the filtered loads of sodium, chloride, and potassium are reabsorbed in thick segment of the ascending limb of loop of Henle

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#Id: 2656

#Unit 7. System Physiology – Animal

An important component of solute reabsorption in the thick ascending limb is the sodium-potassium ATPase pump in the epithelial cell basolateral membranes.

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#Id: 2657

#Unit 7. System Physiology – Animal

In the thick segment of the ascending loop of Henle  reabsorption mechanism is load-dependent.

TLS Online TPP Program

#Id: 2658

#Unit 7. System Physiology – Animal

In the thick segment of the ascending loop of Henle 

Reabsorption of solutes is closely linked to the reabsorptive capability of the sodium-potassium ATPase pump, which maintains a low intracellular

sodium concentration.

TLS Online TPP Program

#Id: 2659

#Unit 7. System Physiology – Animal

In the thick ascending loop, 

Luminal membrane contains a three-ion cotransporter  known as Na+-K+-2Cl- cotransporter