When all the kinetochores have properly attached to spindle microtubules, APC/CCdc20 directs ubiquitinylation of securin and mitotic cyclins

TLS Online TPP Program

#Id: 8519

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8520

#Unit 2. Cellular Organization

Post-translational modifications of tubulin:

Lysine acetylation

Detyrosylation

Polyglutamylation

Polyglycylation

TLS Online TPP Program

#Id: 8521

#Unit 2. Cellular Organization

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.

TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 

ε-amino group of a specific lysine of α-tubulin

Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)

TLS Online TPP Program

#Id: 8523

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8524

#Unit 2. Cellular Organization

Detyrosylation 

tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits.