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TLS Online TPP Program

#Id: 8962

Fate of duplicate gene 

#Unit 11. Evolution and Behavior #Origin of new genes and proteins #Part B Pointers
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TLS Online TPP Program

#Id: 9308

#Unit 4. Cell Communication and Cell Signaling

RPE65 is the enzyme in the pigment epithelial cells of the retina that catalyzes the isomerization of the intermediate esterified all-trans retinol to 11-cis-retinol.
TLS Online TPP Program

#Id: 9309

#Unit 4. Cell Communication and Cell Signaling

Autosomal recessive mutations in the RPE65 gene are a frequent cause of blindness in children.
TLS Online TPP Program

#Id: 9310

#Unit 4. Cell Communication and Cell Signaling

In the dark, 
membrane potential of a rod cell is about −30 mV (Depolarized state)
Rod cells release neurotransmitters (glutamate) constantly
TLS Online TPP Program

#Id: 9311

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 9312

#Unit 4. Cell Communication and Cell Signaling

Depolarized state of a resting rod cell is due to the presence of a large number of open nonselective ion channels that admit both Na+ & Ca2+ into the cell
TLS Online TPP Program

#Id: 9313

#Unit 4. Cell Communication and Cell Signaling

Nonselective cation channels open in response to binding of the second messenger cGMP (cGMP-gated channels)