A G protein– coupled receptor kinase phosphorylates serine and threonine residues in the

cytoplasmic segments of activated GPCRs

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#Unit 4. Cell Communication and Cell Signaling

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#Unit 4. Cell Communication and Cell Signaling

B cell is type of lymphocyte.

B cell synthesized and maturation in bone marrow.

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#Unit 4. Cell Communication and Cell Signaling

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#Unit 4. Cell Communication and Cell Signaling

They are pAPCs

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Cause humoral immunity or antibodies mediated immunity

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#Unit 4. Cell Communication and Cell Signaling

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7(CD80/86)

ICAM-1

MHC-1 and 2 both

CD 22

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#Unit 4. Cell Communication and Cell Signaling

Step involve in formation of mature B-cell