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TLS Online TPP Program

#Id: 9085

Subunit B recognizes and binds to specific gangliosides on the surface of intestinal epithelial cells and provides a route for subunit A to enter. 

#Unit 4. Cell Communication and Cell Signaling #G Protein–Coupled Receptors #Part B Pointers
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TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 
ε-amino group of a specific lysine of α-tubulin
Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)
TLS Online TPP Program

#Id: 8523

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8524

#Unit 2. Cellular Organization

Detyrosylation 
tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits. 
TLS Online TPP Program

#Id: 8525

#Unit 2. Cellular Organization

Detyrosylated microtubules are more stable, because they are more resistant to depolymerization by kinesin-13 and related proteins.
TLS Online TPP Program

#Id: 8526

#Unit 2. Cellular Organization

Polyglutamylation and polyglycylation are likely mutually exclusive, so they would not normally occur at the same time & both can enhance microtubule stability,
TLS Online TPP Program

#Id: 8527

#Unit 2. Cellular Organization

Kinesin-1 associates preferentially with detyrosylated and acetylated microtubules.