Phospholipase C cleaves a phospholipid known as PI(4,5) P2, generating two second messengers: 

diffusible IP3 and membrane-bound DAG

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#Unit 1. Molecules and their Interaction Relevant to Biology

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#Unit 3. Fundamental Processes

UHRF1 also interacts with methylated histone H3, which connects the maintenance of DNA methylation with the stabilization of heterochromatin structure

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#Unit 3. Fundamental Processes

A replication fork is initiated at the origin and then moves sequentially along DNA

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#Unit 4. Cell Communication and Cell Signaling

Mutations in three broad classes of genes have been implicated in the onset of cancer. 

Protooncogenes

Tumor-suppressor genes

genome maintenance genes

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#Unit 3. Fundamental Processes

1. The small fragment (35 kD) possesses a 5’– 3’ exonucleolytic activity, which excises small groups of nucleotides, up to 10 bases at a time.

2. This activity is coordinated with the synthetic/ proofreading activity. 

3. It provides DNA polymerase I with a unique ability to start replication in vitro at a nick in DNA.