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TLS Online TPP Program

#Id: 9086

A1 associates with ARF6, a small G protein in host cells which are accessible only when ARF6 is in its active (GTP-bound) form. 

#Unit 4. Cell Communication and Cell Signaling #G Protein–Coupled Receptors #Part B Pointers
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TLS Online TPP Program

#Id: 8152

#Unit 2. Cellular Organization

After the vesicle coat is complete, the Sec23 coat subunit promotes GTP hydrolysis causes disassembly of the coat.
TLS Online TPP Program

#Id: 8153

#Unit 2. Cellular Organization

A second function of small GTPases in vesicle formation is in the pinching off of a completed vesicle from the parent membrane
TLS Online TPP Program

#Id: 8154

#Unit 2. Cellular Organization

Sar1 GTPase drives the pinching off of COPII vesicles
ARF GTPase drives the pinching off of COPIvesicles
Dynamin GTPase drives the pinching off of clathrin-coated vesicles
TLS Online TPP Program

#Id: 8156

#Unit 2. Cellular Organization

Two different kinds of sorting signals:
Membrane cargo proteins carry cytoplasmic sorting signals
Soluble cargo proteins carry luminal sorting signals
TLS Online TPP Program

#Id: 8157

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8158

#Unit 2. Cellular Organization

Soluble ER-resident proteins contain C-terminal KDEL sorting signal that allows them to be retrieved.