If cells that have incorporated a high level of BrdU are exposed to light, they will photolyse; this has been used to selectively kill newly dividing cells.

TLS Online TPP Program

#Id: 1999

#Unit 3. Fundamental Processes

In wild-type genes, RNA polymerase II terminates transcription at any one of multiple possible sites within about

2 kb of the polyadenylation signal. When the polyadenylation signal is mutated, RNA polymerase II does not terminate transcription, but continues transcription until the next poly(A) site.

TLS Online TPP Program

#Id: 2000

#Unit 3. Fundamental Processes

Histone mRNAs are not polyadenylated; their 3’ ends is recognized by hairpin structure.

TLS Online TPP Program

#Id: 2001

#Unit 3. Fundamental Processes

Histone biogenesis is primarily controlled by the regulation of histone mRNA abundance during the cell cycle. At this G1/S transition, the abundance of histone mRNAs is increased more than 30-fold due to elevated transcription; this process is regulated by the Cyclin E/Cdk2 complex.

TLS Online TPP Program

#Id: 2002

#Unit 3. Fundamental Processes

The rise in histone mRNAs is followed by a rapid decay of histone mRNAs at the end of S phase.

TLS Online TPP Program

#Id: 2003

#Unit 3. Fundamental Processes

SLBP and U7 snRNP generates 3’ end hairpin histone mRNA

TLS Online TPP Program

#Id: 2270

#Unit 3. Fundamental Processes

Formation of any kind of RNA, from any genome called transcription.