Nurturing Life Sciences
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#Id: 2383
#Unit 3. Fundamental Processes
Prp22 helps the release of the mature mRNA from the spliceosome, makes splicing irreversible.
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More than 90% of the genes expressed in mammals are alternatively spliced
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Five ways to splice an RNA
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Steric Hindrance and Combinations of Major and Minor Splice Sites are major reasons behind alternative splicing (Mutually Exclusive Splicing)
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Alternative splicing is often associated with weak splice sites.
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Specific exonic and intronic sequences can enhance or suppress splice site selection.