Nurturing Life Sciences
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#Unit 3. Fundamental Processes
The MCM proteins continue to function at the two bidirectional replication forks as the replication helicase.
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In yeast, the combined action of Cdc6, Cdtl, and the MCM proteins provides the licensing function.
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The replisome exists only as a protein complex associated with the particular structure that DNA takes at the replication fork.
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It does not exist as an independent unit (e.g., analogous to the ribosome), but assembles de novo at the origin for each replication cycle.
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DNA is synthesized in both semiconservative replication and repair reactions.