When sulfated polysaccharide binds to its receptor on the sperm, activates 3 sperm membrane proteins: 

(1) A calcium transport channel

(2) A sodium-hydrogen exchanger

(3) A phospholipase enzyme (IP3)

TLS Online TPP Program

#Id: 1501

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.

 

TLS Online TPP Program

#Id: 1502

#Unit 4. Cell Communication and Cell Signaling

p53 amyloid aggregates,

No transport from cytoplasm to the nucleus

Escape proteasome degradation

TLS Online TPP Program

#Id: 1503

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 demonstrated by biophysical techniques:

X-ray diffraction 

Fourier transform infrared spectroscopy (FTIR)

TLS Online TPP Program

#Id: 3196

#Unit 4. Cell Communication and Cell Signaling

Mutations in three broad classes of genes play key roles in cancer induction: 

Proto-oncogenes genes
Tumor-suppressor genes
Genome maintenance genes

TLS Online TPP Program

#Id: 3197

#Unit 4. Cell Communication and Cell Signaling

Dominant gain-of-function mutations in proto-oncogenes and recessive loss-of-function mutations in tumor-suppressor genes are oncogenic.

TLS Online TPP Program

#Id: 3208

#Unit 4. Cell Communication and Cell Signaling

Mutations in three broad classes of genes play key roles in cancer induction:
Proto-oncogenes genes
Tumor-suppressor genes
Genome maintenance genes