Neutral theory of molecular evolution

Developed by Motoo Kimura, who argued that most of the evolution of DNA sequences occurs by chance (genetic drift) rather than by natural selection. 

TLS Online TPP Program

#Id: 8923

#Unit 2. Cellular Organization

Surveillance mechanisms known as checkpoint pathways responsible for the extraordinarily high fidelity of cell division, ensuring that each daughter cell receives the correct number of accurately replicated chromosomes

TLS Online TPP Program

#Id: 8924

#Unit 2. Cellular Organization

DNA damage response system

halts cell cycle progression and

recruits DNA repair machinery

when DNA is compromised

TLS Online TPP Program

#Id: 8925

#Unit 2. Cellular Organization

The protein kinases DNA-PK, ATM, and ATR are activated at sites of damaged DNA

TLS Online TPP Program

#Id: 8926

#Unit 2. Cellular Organization

ATR activated by single-stranded DNA breaks.

TLS Online TPP Program

#Id: 8927

#Unit 2. Cellular Organization

ATM and DNA-PK are specifically activated by double-strand breaks

TLS Online TPP Program

#Id: 8928

#Unit 2. Cellular Organization

ATM and ATR, activate a triad of related protein kinases: Chk1, Chk2, and MK2