Neutral theory of molecular evolution

Developed by Motoo Kimura, who argued that most of the evolution of DNA sequences occurs by chance (genetic drift) rather than by natural selection. 

TLS Online TPP Program

#Id: 1135

#Unit 2. Cellular Organization

Kinase in cell cycle-

CAK kinase- Activate CDKs

Wee1 kinase- Inhibit CDKs

TLS Online TPP Program

#Id: 1136

#Unit 2. Cellular Organization

Phosphatase in cell cycle-

Cdc25 phosphatase Activates CDKs

Cdc14 phosphatase Activates Cdh1 to degrade mitotic cyclins

TLS Online TPP Program

#Id: 1137

#Unit 2. Cellular Organization

Phosphatase in cell cycle-

Cdc25A phosphatase Activates vertebrate S phase CDKs

Cdc25C phosphatase Activates vertebrate mitotic CDKs

TLS Online TPP Program

#Id: 1138

#Unit 2. Cellular Organization

Inhibitory Proteins in Cell Cycle-

Sic1 - Binds and inhibits S phase CDKs

CKIs p27, p57, and p21- Bind and inhibit CDKs

INK4 - Binds and inhibits G1 CDKs

Rb - Binds E2Fs

TLS Online TPP Program

#Id: 1139

#Unit 2. Cellular Organization

Ubiquitin-Protein Ligases-

SCF- Degradation of phosphorylated Sic1

TLS Online TPP Program

#Id: 1140

#Unit 2. Cellular Organization

Ubiquitin-Protein Ligases-

APC/CCdc20 - Degradation of securin, initiating anaphase, Induces degradation of B-type cyclins