Neutral theory of molecular evolution

Developed by Motoo Kimura, who argued that most of the evolution of DNA sequences occurs by chance (genetic drift) rather than by natural selection. 

TLS Online TPP Program

#Id: 10328

#Unit 4. Cell Communication and Cell Signaling

Engineering T Cells to Recognize Tumor Antigens

When reactivated by inhibition of the immune checkpoint, have the capacity to recognize and kill some tumors with a large burden of mutations.

TLS Online TPP Program

#Id: 10329

#Unit 4. Cell Communication and Cell Signaling

Binding of the extracellular TCR domain to a MHC-peptide complex triggers activation of ZAP70 protein tyrosine kinases attached to the cytosolic domains of the two adjacent ζ chains. 

TLS Online TPP Program

#Id: 10330

#Unit 4. Cell Communication and Cell Signaling

The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 10331

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10332

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10333

#Unit 4. Cell Communication and Cell Signaling