Haldane’s rule: Hybrid sterility or hybrid inviability is often limited to the heterogametic sex. 

TLS Online TPP Program

#Id: 3867

#Unit 5. Developmental Biology

CMF stimulates gene expression in parallel with PSF, and both signals potentiate cAMP signaling by inducing genes involved in cAMP synthesis and detection

TLS Online TPP Program

#Id: 3868

#Unit 5. Developmental Biology

In prespore cells, PKA activation occurs by signalling cascade that is activated by SDF-3, which triggers the synthesis of GABA

TLS Online TPP Program

#Id: 3869

#Unit 5. Developmental Biology

Newly activated genes are:

Adenylate cyclase A (ACA)
PKA
cAMP receptors (cARs)
Extracellular cAMP phosphodiesterase PdsA
An intracellular cAMP phosphodiesterase RegA

TLS Online TPP Program

#Id: 3870

#Unit 5. Developmental Biology

Secreted GABA then acts on prestalk cells to induce the cell-surface exposure of the serine protease domain of the ABC transporter TagC.

TLS Online TPP Program

#Id: 3871

#Unit 5. Developmental Biology

Once all proteins are functioning, a few starving cells start to emit cAMP pulses.

TLS Online TPP Program

#Id: 3872

#Unit 5. Developmental Biology

GABA acts on prespore cells to induce secretion of AcbA.