Binding of ligand to predimerized but inactive RTK alters the conformation of the dimer in such a way that the receptor’s kinase becomes activated.

TLS Online TPP Program

#Id: 1340

#Unit 4. Cell Communication and Cell Signaling

HER1 & HER4, can form stable homodimers after binding a growth factor.

TLS Online TPP Program

#Id: 1341

#Unit 4. Cell Communication and Cell Signaling

HER2 can signal only by forming heterodimers with ligand-bound HER1, HER3, or HER4

TLS Online TPP Program

#Id: 1342

#Unit 4. Cell Communication and Cell Signaling

HER3 lacks a functional kinase domain

TLS Online TPP Program

#Id: 1343

#Unit 4. Cell Communication and Cell Signaling

RAS is a small monomeric G-proteins.

TLS Online TPP Program

#Id: 1344

#Unit 4. Cell Communication and Cell Signaling

RAS is connected to the membrane by a prenylated (lipid) tail.

TLS Online TPP Program

#Id: 1345

#Unit 4. Cell Communication and Cell Signaling

All Ras have the CAAX motifs at the C-terminus.