GRB2 has- 

Phosphotyrosine-binding SH2 domain

Two SH3 domains, bind to Sos

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#Unit 7. System Physiology – Animal

High affinity Neurotrophins  receptors

Tyrosine kinase associated (Trk) receptors 

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#Unit 7. System Physiology – Animal

Low-affinity NGF receptor

p75 NTR (also called NTR 5 neurotrophin receptor) 

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#Unit 7. System Physiology – Animal

p75 NTR forms heteromeric complexes with the different Trk receptors and enhances Trk receptor signaling

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#Unit 7. System Physiology – Animal

Schwann cells and astrocytes produce ciliary neurotrophic factor which promotes the survival of damaged and embryonic spinal cord neurons

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#Unit 7. System Physiology – Animal

A synapse is a site where information is transmitted from one cell to another. 

Types of synapses:

1. electrical synapse

2. chemical synapse

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#Unit 7. System Physiology – Animal

Principle of one-way conduction at chemical synapses 

always transmit the signals in one direction i.e., from the neuron that secretes the neurotransmitter called the presynaptic neuron, to the neuron on which the transmitter acts, called the postsynaptic neuron