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TLS Online TPP Program

#Id: 9665

PI-3 kinase contains SH2 domain which binds to phosphotyrosines on the activated RTKs and cytokine receptors

#Unit 4. Cell Communication and Cell Signaling #Phosphoinositide #Part B Pointers
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TLS Online TPP Program

#Id: 10509

#Unit 4. Cell Communication and Cell Signaling

CED-4 in C. elegans = Apaf-1 in Mammals
TLS Online TPP Program

#Id: 10510

#Unit 4. Cell Communication and Cell Signaling

The principal caspase in C. elegans is CED-3
TLS Online TPP Program

#Id: 10511

#Unit 4. Cell Communication and Cell Signaling

CED-3 in C. elegans = Caspase-9 in mammals
TLS Online TPP Program

#Id: 10512

#Unit 4. Cell Communication and Cell Signaling

EGL-1 protein binds to CED-9, alters its conformation, and catalyzes the release of CED-4 from CED-9
TLS Online TPP Program

#Id: 10513

#Unit 4. Cell Communication and Cell Signaling

Four freed CED-4 dimers combine to form a CED-4 octamer, which binds two molecules of the CED-3 zymogen (an enzymatically inactive precursor) triggers the formation of the active CED-3 protease
TLS Online TPP Program

#Id: 10514

#Unit 4. Cell Communication and Cell Signaling

In mammals
XIAP (inhibitor of apoptosis proteins) restrain both initiator and effector caspases