In resting cells, 

GSK3 is catalytically active which phosphorylates and inhibits glycogen synthase, thus blocking glycogen synthesis from glucose

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Shelterin functions to protect telomeres from DNA damage repair pathways and to regulate telomere length control by telomerase

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#Unit 3. Fundamental Processes

The telomerase uses the 3’–OH of the G+T telomeric strand as a primer for synthesis of tandem TTGGGG repeats.

 

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For the synthesis of telomere, Only dGTP and dTTP are needed for the activity.

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#Unit 3. Fundamental Processes

The telomerase is a large ribonucleoprotein that consists of a templating RNA which is encoded by TLC1 in yeast, hTERC in humans.

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#Unit 3. Fundamental Processes

Telomerase protein component with catalytic activity is encoded by EST2 in yeast, hTERT in humans

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#Unit 3. Fundamental Processes

The RNA component is typically short 159 bases long in Tetrahymena, and 451 bases long in humans, though 1.3 kb in yeast