TLS Online TPP Program

#Id: 6443

#Unit 8. Inheritance Biology

TLS Online TPP Program

#Id: 6444

#Unit 8. Inheritance Biology

Lod (logarithm of odds) scores

To determine the probability that genes are actually linked, geneticists often calculate lod (logarithm of odds) scores. 

TLS Online TPP Program

#Id: 6445

#Unit 8. Inheritance Biology

To obtain a lod score, we calculate 

the probability of obtaining the observed results under the assumption that the genes are linked with a specified degree of recombination

the probability of obtaining the observed results under the assumption of independent assortment.

TLS Online TPP Program

#Id: 6446

#Unit 8. Inheritance Biology

TLS Online TPP Program

#Id: 6447

#Unit 8. Inheritance Biology

Suppose recombination frequency is 0.1, and that the probability of obtaining the same observations under the assumption of independent assortment is 0.0001. 

TLS Online TPP Program

#Id: 6448

#Unit 8. Inheritance Biology

A lod score of 3 or higher is usually considered convincing evidence for linkage.

A lod score of -2 or lower is usually considered convincing evidence for independent assortment.