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TLS Online TPP Program

#Id: 9874

The innate immune system includes physical and chemical—as well as cellular responses

#Unit 4. Cell Communication and Cell Signaling #Innate Immunity #Part B Pointers
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TLS Online TPP Program

#Id: 8606

#Unit 2. Cellular Organization

M phase Cyclin–CDKs
In human - cyclin A-CDK 1
cyclin B-CDK 1
In budding yeast - CIb 1/2/3/4-Cdc 28
TLS Online TPP Program

#Id: 8607

#Unit 2. Cellular Organization

Cdk1 
=Cdc2 (vertebrates and fission yeast)
= Cdc28  (budding yeast)
TLS Online TPP Program

#Id: 8608

#Unit 2. Cellular Organization

There are three D cyclins in mammals:
cyclins D1, D2, and D3
TLS Online TPP Program

#Id: 8609

#Unit 2. Cellular Organization

In free CDK2, the A-loop blocks access of protein substrates to the γ phosphate of the bound ATP.
TLS Online TPP Program

#Id: 8610

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8611

#Unit 2. Cellular Organization

Nonphosphorylated CDK bound to one of its cyclin partners has minimal but detectable protein kinase activity in vitro, although it may be essentially inactive in vivo.