FOXP1 is a transcription factor which stimulate the production of Oct4 and Nanog and establish pluripotency. Which of the following statements are correct regarding to the mechanism of alternative splicing of FOXP1. 

A. There are two isoforms of the FoxP1 protein, One is the product of an mRNA spliced to include a particular exon, 18b, while the other splicing variant carries exon 18a.

B. When alternative splicing generates a form including exon 18b in place of 18a, the resulting isoform (FOXP1-ES) binds to a different DNA sequence and thus controls expression of a different set of genes.

C. The protein encoded by the exon 18b– carrying mRNA is called FOXP1-ES it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation. 

D. The exon 18a– containing form encodes FOXP1 itself, and this has the opposite effect: this activates genes that promote dedifferentiation, and thus stimulates iPS cell formation.

TLS Online TPP Program

#Question id: 27974

#Unit 1. Molecules and their Interaction Relevant to Biology

During the reduction of C in Q cycle four proton transported from matrix to IMS in which

TLS Online TPP Program

#Question id: 27975

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following set of condition During Q cycle, will favours the formation of ROS generation

(a) mitochondria are not making ATP and therefore have a large proton-motive force and a high ratio of QH2/Q

(b) mitochondria are making ATP and therefore have a large proton-motive force and a high ratio of Q/QH2 

(c) there is a high NAD/NADH ratio in the matrix

(d) there is a high NADH/NAD ratio in the matrix

TLS Online TPP Program

#Question id: 27976

#Unit 1. Molecules and their Interaction Relevant to Biology

Ubiquinone (Q) is the point of entry from 4 major entry points

a. NADH

b. Succinate (MM)

c. Glycerol 3-phosphate dehydrogenase (Cytosol)

d. Acyl-CoA dehydrogenase

TLS Online TPP Program

#Question id: 27977

#Unit 1. Molecules and their Interaction Relevant to Biology

Respiratory complexes tightly associate with each other in the inner membrane to form respirasomes 

a. I, II, III by Cytcox

b. III-IV by UQH2 ⇌ UQ 

c. I, II, III by UQH2 ⇌ UQ 

d. III-IV by Cytc_ox

TLS Online TPP Program

#Question id: 27978

#Unit 1. Molecules and their Interaction Relevant to Biology

Alternative oxidase are characteristically found in plant responsible for the

TLS Online TPP Program

#Question id: 27979

#Unit 1. Molecules and their Interaction Relevant to Biology

In the Alternative respiratory pathway 

a. the external NADH dehydrogenase is rotenone insensitive 

b. the external NADH dehydrogenase is cyanide-resistant

c. alternative oxidase is cyanide-resistant 

d. alternative oxidase is rotenone insensitive