TLS Online TPP Program

#Question id: 15305


The multi-hit model, which proposes that multiple mutations are needed to cause cancer, which of the following is incorrect regarding to this model?

#Unit 4. Cell Communication and Cell Signaling
  1. is consistent with the genetic homogeneity of cells from a given tumor
  2. increase in the incidence of human cancers with advancing age 
  3. loss of function mutation in tumor-suppressor gene and proto-oncogenes
  4. the cooperative effect of oncogenic transgenes and tumor-suppressor gene mutations
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TLS Online TPP Program

#Question id: 4510

#Unit 3. Fundamental Processes

Which statements are true about group I and group II introns,

A. Group I (and II) introns are not enzymes because they have a turnover number of only 1.

B. A third transesterification reaction can occur to cyclize the intron.

C. They cannot be readily converted into ribozymes.

D. It is similar to the way that the self-cleaving Hammerhead could be converted to a ribozyme by separating the active site from the substrate

TLS Online TPP Program

#Question id: 4511

#Unit 3. Fundamental Processes

The proteins are not needed for the splicing reaction itself, because

TLS Online TPP Program

#Question id: 4512

#Unit 3. Fundamental Processes

Some pre-mRNAs can be spliced in more than one way. Thus, mRNAs containing different selections of exons can be generated from a given pre-mRNA, called

TLS Online TPP Program

#Question id: 4513

#Unit 3. Fundamental Processes

Different snRNPs recognize the same (or overlapping) sequences in the pre-mRNA at different stages of the splicing reaction, which two snRNPs recognizing the 5’ splice site

TLS Online TPP Program

#Question id: 4514

#Unit 3. Fundamental Processes

What is true about coactivators,

A. The coactivators act directly by binding to the DNA

B. The coactivators act indirectly—not by binding to the DNA

C. Are required for essential communication between the activators and the complex composed of Pol II.

D. Are required for essential communication between the and the basal (or general) transcription factors.

TLS Online TPP Program

#Question id: 4515

#Unit 3. Fundamental Processes

Transcription Activators are,

A. Known to facilitate transcription at hundreds of promoters,

B. Specific for a few promoters,

C. Sensitive to the binding of signal molecules,

D. Providing the capacity to activate or deactivate transcription in response to a changing cellular environment.