TLS Online TPP Program

#Question id: 15365


The MDM2 protein in its active form can form a complex with p53, inhibiting the transcription factor and causing p53 ubiquitinylation and subsequent proteasomal degradation, ATM phosphorylates MDM2 to inactivate it, causing increased stabilization of p53, but there is one another gene or key regulator which controls the level of MDM2;

#Unit 4. Cell Communication and Cell Signaling
  1. PR-p14ARF, NR-MDM2
  2. Chk2
  3. p14ARF 
  4. Cdc25A