TLS Online TPP Program

#Question id: 15365


The MDM2 protein in its active form can form a complex with p53, inhibiting the transcription factor and causing p53 ubiquitinylation and subsequent proteasomal degradation, ATM phosphorylates MDM2 to inactivate it, causing increased stabilization of p53, but there is one another gene or key regulator which controls the level of MDM2;

#Unit 4. Cell Communication and Cell Signaling
  1. PR-p14ARF, NR-MDM2
  2. Chk2
  3. p14ARF 
  4. Cdc25A
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TLS Online TPP Program

#Question id: 11080

#Unit 7. System Physiology – Animal

The O2-CO2 diagram here shows a ventilation-perfusion ratio line for the normal lung. Which of the following best describes the effect of decreasing ventilation-perfusion ratio on the alveolar Po2 and Pco2?


TLS Online TPP Program

#Question id: 11081

#Unit 7. System Physiology – Animal

In which of the following conditions is alveolar Po2 increased and alveolar Pco2 decreased?

TLS Online TPP Program

#Question id: 11082

#Unit 7. System Physiology – Animal

A 67-year-old man has a solid tumor that pushes against an airway partially obstructing air flow to the distal alveoli. Which point on the ventilation-perfusion line of the O2-CO2 diagram corresponds to the alveolar gas of these distal alveoli?


TLS Online TPP Program

#Question id: 11083

#Unit 7. System Physiology – Animal

A 55-year-old male has a pulmonary embolism that partially blocks the blood flow to his right lung. Which point on the ventilation-perfusion line of the O2-CO2 diagram corresponds to the alveolar gas of his right lung?


TLS Online TPP Program

#Question id: 11084

#Unit 7. System Physiology – Animal

The next diagram shows two lung units (S and T) with their blood supplies. Lung unit S has an ideal relationship between blood flow and ventilation. Lung unit T has a comprised blood flow. What is the relationship between alveolar dead space (DALV), physiologic dead space (DPHY) and anatomic dead space (DANAT) for these lung units?


TLS Online TPP Program

#Question id: 11085

#Unit 7. System Physiology – Animal

The diagrams show changes in the partial pressures of oxygen and carbon dioxide as blood flows from the arterial end to the venous of the pulmonary capillaries. Which diagram best depicts the normal relationship between Po2 (red line) and Pco2 (green line) during resting conditions?