Changes in DNA methylation, as well as changes in the activity of histone-modifying enzymes or chromatin-remodeling complexes, are major drivers of tumorigenesis,

a. Hypermethylation of CpG dinucleotides of TSG gene causes cancer.

b. Hypomethylation of CpG dinucleotides of proto-oncogenes causes cancer.

c. SWI/SNF plays a role in repressing the expression of E2F genes.

d. Gain of SWI/SNF function, just like loss of Rb function.

Which of the statements are INCORRECT;

TLS Online TPP Program

#Question id: 862

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following

lysosomal protein degradation pathways	Found in
1. Nonselective	a-well-nourished cells	i-containing the pentapeptide Lys-Phe-Glu-Arg-Gln
2- Selective	b-starving cells

TLS Online TPP Program

#Question id: 863

#Unit 1. Molecules and their Interaction Relevant to Biology

Ubiquitinated proteins are proteolytically degraded in an ATP-dependent process mediated by a large (∼2500 kD, 26S) multiprotein complex named the 26S proteasome;

TLS Online TPP Program

#Question id: 864

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one is not the appropriate function of Heat Shock Proteins;

TLS Online TPP Program

#Question id: 865

#Unit 1. Molecules and their Interaction Relevant to Biology

In autophagy, the endoplasmic reticulum (ER) first gives rise to a cup-shaped, membranous cisterna called the______

TLS Online TPP Program

#Question id: 866

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is known as Sanger’s reagent

TLS Online TPP Program

#Question id: 867

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the correct diseases with their precursors

Disease	Protein or precursor involved in disease
1. Cystic fibrosis	a. Prion protein
2. Creutzfeldt–Jakob disease	b. CFTR
3. Familial hypercholesterolaemia	c. LDL receptor
4. fatal familial insomnia	d. β-amyloid protein
5. Alzheimer’s disease	e. β-hexosaminidase