TLS Online TPP Program

#Question id: 15369


Changes in DNA methylation, as well as changes in the activity of histone-modifying enzymes or chromatin-remodeling complexes, are major drivers of tumorigenesis,
a. Hypermethylation of CpG dinucleotides of TSG gene causes cancer.
b. Hypomethylation of CpG dinucleotides of proto-oncogenes causes cancer.
c. SWI/SNF plays a role in repressing the expression of E2F genes.
d. Gain of SWI/SNF function, just like loss of Rb function.
Which of the statements are INCORRECT;

#Unit 4. Cell Communication and Cell Signaling
  1.  a and b 
  2. Only c
  3. c and d
  4.  Only D
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TLS Online TPP Program

#Question id: 4267

#Unit 3. Fundamental Processes

The 3D structure of the complete Escherichia coli ribosome with bound mRNA and tRNAs revealed that the very amino terminus of one protein (L27) does reach into the active site. This finding suggested a role for this protein in catalysis. To test this possibility, the nine amino acids at the L27 amino terminus that were in close proximity to the active site were eliminated by mutation. The following possible outcomes were found to be correct as

A. The resulting cells produced ribosomes with reduced but detectable peptidyl transferase activity

B. Region of the L27 protein contributes to peptidyl transferase activity

C. The mutant ribosomes, didn’t synthesised wildtype levels of cells

D. Vast majority of this increase in peptide bond formation is retained, even without the presence of L27 in the active site

E. The most likely role for L27 is to correctly position one or more of the RNA components of the active site

TLS Online TPP Program

#Question id: 29589

#Unit 6. System Physiology – Plant

Which one of the following reactions takes place during the reduction phase of the Calvin- Benson cycle?

TLS Online TPP Program

#Question id: 3690

#Unit 3. Fundamental Processes

The DNA polymerase is a template-directed enzyme that synthesizes new complementary strand from a parent strand but it requires the existing short nucleotide sequence for its elongation. Which of the following enzyme is required for the synthesis of this primer?

TLS Online TPP Program

#Question id: 7479

#General Aptitude

How many times to the hands of a clock coincide in 36 hour?

TLS Online TPP Program

#Question id: 24603

#Unit 2. Cellular Organization

Presence of introns leads to which phenomenon