Most tumors induce the formation of new blood vessels that invade the tumor and nourish it, a process called angiogenesis. Following statements are regarding to angiogenesis. A. Angiogenesis allow the tumor to increase in size and thus increase the probability that additional harmful mutations will occur. B. Angiogenesis also facilitates the process of metastasis. C. The VEGF receptors, which are tyrosine kinases, regulate several aspects of angiogenesis such as endothelial cell survival and growth, endothelial cell migration, and vessel wall permeability. D. VEGF expression can be induced by oncogenes and by hypoxia, defined as a partial pressure of oxygen of more than 7 mmHg. E. A transcription factor VEGF is activated in low-oxygen conditions and which binds to and induces transcription of the HIF-1 gene which affect the probability of tumor growth by angiogenesis. Which of the following statements are incorrect? -triyambak.org