Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome. A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9. B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated. C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins. D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins. Which of the following statements are incorrect? -triyambak.org