Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.

A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.

B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.

C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.

D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.

Which of the following statements are incorrect?

#Question id: 7162

#Unit 5. Developmental Biology

Is regeneration in Hydra similar to regeneration in vertebrates, or is it fundamentally different in some way?

#Question id: 7163

#Unit 5. Developmental Biology

What statement is correct when comparing morphallaxis and epimorphosis?

#Question id: 7164

#Unit 5. Developmental Biology

If an amphibian zygote is manipulated so that the first cleavage plane fails to divide the gray crescent, then ________.

#Question id: 7165

#Unit 5. Developmental Biology

Embryonic induction, the influence of one group of cells on another group of cells, plays a critical role in embryonic development. In 1924, Hans Spemann and Hilde Mangold transplanted a piece of tissue that influences the formation of the notochord and neural tube, from the dorsal lip of an amphibian embryo to the ventral side of another amphibian embryo. If embryonic induction occurred, which of the following observations justifies the claim of embryonic induction?

#Question id: 7166

#Unit 5. Developmental Biology

Just prior to the onset of gastrulation in an embryo, the "organizer" cells are specified. If you were to experimentally block the specification of these cells, what would you expect the result to be in the developing embryo?

#Question id: 7167

#Unit 5. Developmental Biology

The following experiment is designed to study the role of several hormones in the regulation of metamorphosis in frogs.

These results suggest which of the following about prolactin (group 2 and group 7) at the dose tested?