Conversion of a proto-oncogene into an oncogene, also called activation, generally involves a gain-of-function mutation. Following statements are regarding to the mechanisms that produce oncogenes from the corresponding proto-oncogenes.

A. A change in a single base pair in a proto-oncogene that results in a hyperactive or constitutively active protein product.

B. A chromosomal translocation that fuses two genes together to produce a hybrid gene encoding a chimeric protein whose activity, unlike that of the parent proteins, is permanently suppress.

C. A chromosomal translocation that brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene.

D. Amplification of a DNA segment including a proto-oncogene so that numerous copies exist, leading to overproduction of the encoded protein.

Which of the following statements are correct?

TLS Online TPP Program

#Question id: 23849

#Unit 2. Cellular Organization

Which pathway regulates the contraction of vertebrate smooth muscle? 

TLS Online TPP Program

#Question id: 23850

#Unit 2. Cellular Organization

Match the following class of myosin (Column I)  with their function (Column II)

COLUMN I	COLUMN II
A. Myosin I	i. Organelle transport
B. Myosin II	ii. Contraction
C. Myosin V	iii. Membrane association, endocytosis

TLS Online TPP Program

#Question id: 23851

#Unit 13. Methods in Biology

DNA fragments from a gel are transferred to a nitrocellulose paper during the procedure called Southern blotting. What is the purpose of transferring the DNA from a gel to a nitrocellulose paper?

TLS Online TPP Program

#Question id: 23852

#Unit 13. Methods in Biology

RFLP analysis can be used to distinguish between alleles based on differences in which of the following?

TLS Online TPP Program

#Question id: 23853

#Unit 13. Methods in Biology

The segment of DNA shown in Figure, has restriction sites I and II, which create restriction fragments A, B, and C. Which of the gels produced by electrophoresis shown below best represents the separation and identity of these fragments? 

TLS Online TPP Program

#Question id: 23854

#Unit 13. Methods in Biology

Which of the following procedures would produce RFLPs?