Following statements are regarding to the apoptosis which is induced by trophic factors.

A. The presence of specific trophic factors (e.g., NGF) leads to activation of their cognate receptor tyrosine kinases (e.g., TrkA) and activation of the PKB pathway.

B. DNA damage or ultraviolet irradiation leads to induction of synthesis of the BH3-only Puma protein. Puma binds to Bak and Bax as well as to Bcl-2, allowing Bak and Bax to form oligomeric pores.

C. Removal of a cell from its substratum disrupts integrin signaling, leading to release of the BH3-only Bim protein from the cytoskeleton.

D. Binding of extracellular death signals, such as tumor necrosis factor and Fas ligand, to their receptors oligomerizes an associated protein (FADD), which in turn triggers the caspase cascade, leading to cell murder by apoptosis.

Which of the following pathway does not belong to the trophic factor inducing apoptotic pathway?

TLS Online TPP Program

#Question id: 27065

#Unit 1. Molecules and their Interaction Relevant to Biology

Determine R and S Configurations On A Fischer Projection given below 

TLS Online TPP Program

#Question id: 27066

#Unit 1. Molecules and their Interaction Relevant to Biology

Determine R and S Configurations On A Fischer Projection given below 

TLS Online TPP Program

#Question id: 27067

#Unit 1. Molecules and their Interaction Relevant to Biology

Choose the correct statement regarding the stereochemistry of amino acid

1. 16 amino acid except (Thr, Ile, Cys, Gly) L Fischer projection is equal to S and D is equal to R configuration 

2. Thr, Ile is special case because of two chiral center exist in L – Ile/Thr – 2S,3R and D-Ile/Thr–2R,3S configuration  

3. Cys exiest in L- Cys – R & D- Cys – S configuration 

4. Gly is optically inactive 

TLS Online TPP Program

#Question id: 27068

#Unit 1. Molecules and their Interaction Relevant to Biology

Isoleucine and Threonine have two chiral carbons so exists in multiple RS configuration, choose the correct option regarding the given fig.

1. a is D-threonine is (2S, 3S) threonine

2. b is L-threonine is (2R,3S) threonine

3. a is L-threonine is (2S, 3R) threonine

4. b is D-threonine is (2R,3S) threonine

TLS Online TPP Program

#Question id: 27069

#Unit 1. Molecules and their Interaction Relevant to Biology

Choose the correct option regarding the stereochemistry of given compound 

TLS Online TPP Program

#Question id: 27070

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statements is correct regarding the stereochemistry of Thr, Ile 

1. Thr, Ile is special case because of two chiral center exist in L-Ile in 2R,3S and L-Thr in 2R,3S configuration 

2. Thr, Ile is special case because of two chiral center exist in D-Ile in 2R,3S and D-Thr in 2R,3S configuration 

3. Thr, Ile is special case because of two chiral center exist in L–Ile in 2S,3R and L–Thr in 2S,3R 

4. Thr, Ile is special case because of two chiral center exist in D–Ile in 2S,3R and D–Thr in 2S,3R