Following statements are regarding to the apoptosis which is induced by trophic factors.

A. The presence of specific trophic factors (e.g., NGF) leads to activation of their cognate receptor tyrosine kinases (e.g., TrkA) and activation of the PKB pathway.

B. DNA damage or ultraviolet irradiation leads to induction of synthesis of the BH3-only Puma protein. Puma binds to Bak and Bax as well as to Bcl-2, allowing Bak and Bax to form oligomeric pores.

C. Removal of a cell from its substratum disrupts integrin signaling, leading to release of the BH3-only Bim protein from the cytoskeleton.

D. Binding of extracellular death signals, such as tumor necrosis factor and Fas ligand, to their receptors oligomerizes an associated protein (FADD), which in turn triggers the caspase cascade, leading to cell murder by apoptosis.

Which of the following pathway does not belong to the trophic factor inducing apoptotic pathway?

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#Question id: 7589

#General Aptitude

A train of length 500 m crosses a platform of length 50% more than the length of the train in 50 seconds. Find the time taken by this train to cross another train of same length running with double the speed of first train in the opposite direction.

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#Question id: 7590

#General Aptitude

The ratio of the length of two trains X and Y is 4 : 7 and the ratio of the time taken by both trains to cross a man standing on a platform is 2 : 3. If the speed of the train y m/sec

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#Question id: 7591

#General Aptitude

A pilot flies an aircraft at a certain speed for a distance of 800 km. He could have saved 40 min by increasing the average speed of the plane by 40 km/h. Find the average speed of the aircraft.

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#Question id: 7592

#General Aptitude

A train started from point A at a speed of 60 km/hr and after 2 hours another train of same length started from A at a speed of 80 km/hr in the same direction as the first one. After how much time the second train will meet the first train?

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#Question id: 7593

#General Aptitude

An aeroplane files along the four sides of a square at the speeds of 200 , 400 , 600 and 800 km/hr. Find the average speed of the plane around the field

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#Question id: 7594

#General Aptitude

A car travels the first one third of a certain distance with a speed of 10 km/hr , the next one third distance with a speed of 20 km/hr , and the last one third distance with a speed of 60 km/hr . The average speed of the car for the hole journey is :