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TLS Online TPP Program

#Question id: 1528

Mutation of p53 is described as a dominant-negative mutation. Which of the following statement is correct regarding to the mechanism by which this mutation causes the dominant-negative phenotype?

#Unit 4. Cell Communication and Cell Signaling

  1. Mutation of p53 is a dominant-negative mutation because the active protein is a dimer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

  2. Mutation of p53 is a dominant-negative mutation because the active protein is a pentamer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

  3. Mutation of p53 is a dominant-negative mutation because the active protein is a tetramer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

  4. Mutation of p53 is a dominant-negative mutation because the active protein is a heptamer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

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TLS Online TPP Program

#Question id: 2192

#Unit 2. Cellular Organization

Site-directed cross-linking is a technique that gives insight into what property of integral membrane proteins?
TLS Online TPP Program

#Question id: 18941

#Unit 13. Methods in Biology

With the construction of cDNA libraries in which each gene is fused to an epitope tag, investigators can precipitate the protein product of a gene by complexing it with the antibody that binds the epitope, a process called 
TLS Online TPP Program

#Question id: 16138

#Unit 13. Methods in Biology

You obtain 6 BACs (of known order, as shown below) and 7 STSs (of unknown order) that derive from a region of mouse chromosome 16 whose genomic sequence has not yet been finished.   
 
By PCR (using 20-bp primers at either end of each STS), you test each of the 6 BACs for the presence (+) or absence (-) of each of the 7 STSs. You obtain the following results:
 
Would you expect STS51 and STS52 to be present in BAC D? 
TLS Online TPP Program

#Question id: 23222

#Unit 2. Cellular Organization

Which ratio of bacteria is high compared to the same ratio for larger organisms of similar shape?
TLS Online TPP Program

#Question id: 12762

#Unit 10. Ecological Principles

Find  appropriate option for  given question . The figure above depicts the intensity versus frequency curve of an a2coustical receptor of the larva of a noctuid moth. The larva is preyed on by a wasp whose vibrating wings produce a0buzz.
On the basis of the figure, it can be predicted that the wasp buzz 1has a frequency