#Question id: 1506
#Unit 4. Cell Communication and Cell Signaling
An oncogene codes for a growth factor receptor that is constitutively active. Of the following statements about a culture of cells expressing this gene, which would you expect to be true?
#Question id: 1507
#Unit 4. Cell Communication and Cell Signaling
The genes responsible for cancer in RNA and DNA tumor viruses are:
#Question id: 1508
#Unit 4. Cell Communication and Cell Signaling
Of the following statements explaining how alterations of the ras gene cause cancer, which is true?
#Question id: 1509
#Unit 4. Cell Communication and Cell Signaling
Cells that are infected, damaged, or have reached the end of their functional life span often undergo "programmed cell death." This controlled cell suicide is called apoptosis. Select the appropriate description of this event on a cell's life cycle.
#Question id: 1510
#Unit 4. Cell Communication and Cell Signaling
Match the correct protein (Column I) with their function (Column II) during apoptosis.
Column I |
Column II |
A. Puma |
I. Pro-survival protein |
B. Bak |
II. Zymogen |
C. Mcl-1 |
III. Pro-apoptotic protein |
D. CED-3 |
IV. BH3-only protein |
#Question id: 1511
#Unit 4. Cell Communication and Cell Signaling
Most tumors induce the formation of new blood vessels that invade the tumor and nourish it, a process called angiogenesis. Following statements are regarding to angiogenesis.
A. Angiogenesis allow the tumor to increase in size and thus increase the probability that additional harmful mutations will occur.
B. Angiogenesis also facilitates the process of metastasis.
C. The VEGF receptors, which are tyrosine kinases, regulate several aspects of angiogenesis such as endothelial cell survival and growth, endothelial cell migration, and vessel wall permeability.
D. VEGF expression can be induced by oncogenes and by hypoxia, defined as a partial pressure of oxygen of more than 7 mmHg.
E. A transcription factor VEGF is activated in low-oxygen conditions and which binds to and induces transcription of the HIF-1 gene which affect the probability of tumor growth by angiogenesis.
Which of the following statements are incorrect?