TLS Online TPP Program

#Question id: 2523


Which of the following in not true of the nuclear envelope?

#Unit 2. Cellular Organization
  1. The nuclear envelope is exactly like other cellular membranes.

  2. The nuclear envelope separates the genetic material from the cytoplasm.

  3. The nuclear envelope is a pair of concentric membranes.

  4. The nuclear envelope is studded with pores.

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TLS Online TPP Program

#Question id: 1536

#Unit 4. Cell Communication and Cell Signaling

Use the following figure to answer the question. According to figure, which of the following statement is incorrect?

TLS Online TPP Program

#Question id: 1537

#Unit 4. Cell Communication and Cell Signaling

Transformation of mature cells may also occur due to aberrant expression of stemness genes, resulting in cell clones with a dedifferentiated phenotype and self-renewing capacity resembling stem cells. Recent experimental evidence supporting this proposal has been provided with the induction of adult somatic cells into pluripotent stem (iPS) cells through ectopic expression of four genes encoding the pluripotency factors Oct4 and Sox2, the transcription factor Klf4, and the oncoprotein c-Myc in mouse or human fibroblasts. However, along with pluripotency comes the capability of generating teratomas. On the basis of the above information which of the following outcome is most appropriate?

TLS Online TPP Program

#Question id: 1538

#Unit 4. Cell Communication and Cell Signaling

Many aspects of the biology of stem cells, including maintenance of pluripotency, self-renewal, and differentiation, are controlled by the phenomenon of RNA interference involving a variety of small molecules of RNA.

Match the following miRNA (Column I) with their target gene (Column II).

Column I

Column II

a. Let-7 miRNA

i. Bcl-2

b. miR-16

ii. PTEN phosphatase

c. miR-125a and miR-125b

iii. Myc

d. miR-21

iv. LIN28

TLS Online TPP Program

#Question id: 15303

#Unit 4. Cell Communication and Cell Signaling

Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by
a.  Loss of both alleles of NF1
b.  Mutation in RAS GAP-type protein
c.  A single mutant NF1 allele
d.  Mutation in SRC protein

TLS Online TPP Program

#Question id: 15304

#Unit 4. Cell Communication and Cell Signaling

An activating mutation of one of the two alleles of a proto-oncogene converts it into an oncogene, This can occur by EXCEPT

TLS Online TPP Program

#Question id: 15305

#Unit 4. Cell Communication and Cell Signaling

The multi-hit model, which proposes that multiple mutations are needed to cause cancer, which of the following is incorrect regarding to this model?