Practice Questions

TLS Online TPP Program

#Question id: 2551

Gaucher disease is the most common of lipid storage diseases in humans. It is caused by a deficiency of an enzyme necessary for the breakdown of lipids. This leads to the accumulation of fatty material in organs of the body including the spleen, liver, kidneys, lungs, brain, and bone marrow. Using your knowledge of the structure of eukaryotic cells, identify the statement below that best explains how internal membranes and the organelles of cells may be involved in Gaucher disease.

#Unit 2. Cellular Organization

The mitochondria are most likely defective and do not produce adequate amounts of ATP needed for cellular energy.
The rough endoplasmic reticulum contains too many ribosomes, which results in an overproduction of the enzyme involved in lipid breakdown.
The lysosomes lack sufficient amounts of enzymes necessary for the metabolism of lipids.
The Golgi apparatus produces vesicles with faulty membranes, which fail to be transported to the plasma membrane for secretion.