Gaucher disease is the most common of lipid storage diseases in humans. It is caused by a deficiency of an enzyme necessary for the breakdown of lipids. This leads to the accumulation of fatty material in organs of the body including the spleen, liver, kidneys, lungs, brain, and bone marrow. Using your knowledge of the structure of eukaryotic cells, identify the statement below that best explains how internal membranes and the organelles of cells may be involved in Gaucher disease.

#Question id: 598

#Unit 1. Structure and Function of Biomolecules

Which might be a method used for distinguishing among several mechanistic possibilities in a multi-substrate reaction?

#Question id: 599

#Unit 1. Structure and Function of Biomolecules

In a certain enzyme-catalyzed reaction the following steps occur:

1. A phosphate group on substrate A is transferred to a side chain of an active site residue of the enzyme.

2. The dephosphorylated form of substrate A dissociates from the enzyme.

3. Substrate B enters the active site and is phosphorylated with simultaneous regeneration of the enzyme in its original form.

What kind of kinetic mechanism is described?

#Question id: 600

#Unit 1. Structure and Function of Biomolecules

Two substances are used to produce a certain biological product in an enzyme-catalyzed reaction. It is found that both substrates must bind to the enzyme, first one, then the other before the product is produced. This is an example of a/an ________.

#Question id: 601

#Unit 1. Structure and Function of Biomolecules

In a ping-pong reaction which does not occur?

#Question id: 602

#Unit 1. Structure and Function of Biomolecules

An inhibitor binds to a site other than the active site of the enzyme. Which statement below correlates with this observation?

#Question id: 603

#Unit 1. Structure and Function of Biomolecules

Nonclassical competitive inhibition involves ________.