Following statements are regarding to mechanism of kinesin-1 movement. A. Initially leading head tightly bound to the microtubule and not bound by any nucleotide, while the trailing head is weakly bound to the microtubule and has ADP bound. B. Binding of ATP induces a conformational change causing the linker to swing forward and dock into the head. This motion swings the former trailing head to become the leading head. C. Binding of ATP induces a conformational change causing the linker to swing forward and dock into the head. This motion swings the former leading head to become the trailing head. D. When leading head releases ADP and coordinately the trailing head hydrolyzes ATP to ADP + Pi. Pi is released and the linker becomes undocked. E. When trailing head releases ADP and coordinately the leading head hydrolyzes ATP to ADP + Pi. Pi is released and the linker becomes undocked. Which of the following combination is correct? -triyambak.org