#Question id: 1498
#Unit 4. Cell Communication and Cell Signaling
Would you expect to find that the cells of children with nonfamilial (i.e., sporadic) retinoblastoma have the chromosomal deletion referred to in number (9) above?
#Question id: 1499
#Unit 4. Cell Communication and Cell Signaling
The normal protein product of the RB gene acts as an:
#Question id: 1500
#Unit 4. Cell Communication and Cell Signaling
Which of the following is not a normal function of p53?
#Question id: 1501
#Unit 4. Cell Communication and Cell Signaling
When a culture of rodent cells is infected with a DNA tumor virus whose gene products bind to p53 and RB, all the cells take on characteristics of malignancy. If the viral gene coding the p53-binding protein is mutated, but that coding for the RB-binding protein is not mutated, how will infected cells respond?
#Question id: 1502
#Unit 4. Cell Communication and Cell Signaling
The textbook states that cells of patients with adenomatous polyposis coli (APC) “contain a deletion of a small portion of chromosome #5, which was subsequently identified as the site of a tumor-suppressor gene called APC.” In which cells of these patients would you expect to find this chromosomal deletion?
#Question id: 1503
#Unit 4. Cell Communication and Cell Signaling
When the genes responsible for familial breast cancer were sequenced, it was found that the polypeptides they encoded contained a zinc finger motif. What does this suggest to you about the normal functions of the products of these genes?