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TLS Online TPP Program

#Question id: 23863

In 1997, Dolly the sheep was cloned. Which of the following processes was used?

#Unit 14. Methods in Biology
  1. use of mitochondrial DNA from adult female cells of another ewe
  2. replication and dedifferentiation of adult stem cells from sheep bone marrow
  3. separation of an early-stage sheep blastula into separate cells, one of which was incubated in a surrogate ewe
  4. fusion of an adult cellʹs nucleus with an enucleated sheep egg, followed by incubation in a surrogate
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TLS Online TPP Program

#Question id: 28916

#Unit 4. Cell Communication and Cell Signaling

Which of the following hedgehog (Hh) proteins promotes spermatogenesis?
TLS Online TPP Program

#Question id: 28917

#Unit 4. Cell Communication and Cell Signaling

Find out the correct match of Vertebrates hedgehog gene with their characteristics;

 hedgehog gene characteristics
 I- Sonic hedgehog (shh) (a) It is found in the Sertoli cells of the testes
 II- desert hedgehog (dhh) (b) It is expressed in the gut and cartilage and is important in postnatal bone growth 
 III- indian hedgehog (ihh) (c) It is an essential for normal patterning of the limbs
TLS Online TPP Program

#Question id: 28918

#Unit 4. Cell Communication and Cell Signaling

Which of the following statements is correct about Sonic hedgehog?
TLS Online TPP Program

#Question id: 28919

#Unit 4. Cell Communication and Cell Signaling

Given some statements about Hedgehog processing and secretion;
a) autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion 
b) autoproteolytic activity that cleaves off the N-terminus to reveal a signal sequence that marks the protein for secretion 
c) Secretion requires the addition of cholesterol and palmitic acid
d) Secretion requires the  modification of Hh by Glycosylation
Which of the following is correct prediction about processing and secretion of Hh?
TLS Online TPP Program

#Question id: 28920

#Unit 4. Cell Communication and Cell Signaling

Which of the following is a correct prediction about processing and secretion of Hedgehog protein ?
a) the freed N-terminal is not involved in signaling and is often degraded
b) the freed C-terminal is not involved in signaling and is often degraded
c) the N-terminal becomes the active Hedgehog protein intended for secretion
d) the C-terminal becomes the active Hedgehog protein intended for secretion
TLS Online TPP Program

#Question id: 28921

#Unit 4. Cell Communication and Cell Signaling

Which of the following modification is required for the Secretion of Hh protein?