TLS Online TPP Program

#Question id: 4101


In order to ensure that only fully processed mature mRNAs are allowed to be exported to cytosol, pre-mRNAs associated with snRNPs are retained in the nucleus. To demonstrate this, an experiment was performed where a gene coding a pre-mRNA with a single intron was mutated either at the 5’ or 3’ splice sites or both the splice sites.

Given below are a few possible outcomes, Choose NOT FEASIBLE OUTCOME

A. Pre-mRNA having mutation at both the splice sites will be retained in the nucleus because of the presence of bound snRNPs.

B. Pre-mRNA having mutation at both the splice sites will be exported to cytosol because of the absence of bound snRNPs.

C. Pre-mRNA mutated at either 3’ or 5’ splice sites will be retained in the nucleus because of the presence of bound snRNPs.

D. Pre-mRNA mutated at either 3’ or 5’ splice sites will be exported to cytosol because of the absence of bound snRNPs.

#Unit 3. Fundamental Processes
  1. B and C   

  2. A and D

  3. B and D   

  4. A and C