TLS Online TPP Program

#Question id: 4319


Why are BRCA1 and BRCA2 considered to be tumor-suppressor genes?

#Unit 3. Fundamental Processes
  1. Their normal products participate in repair of DNA damage.

  2. The mutant forms of either one of these prevent breast cancer.

  3. The normal genes make estrogen receptors.

  4. They block penetration of breast cells by chemical carcinogens.

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TLS Online TPP Program

#Question id: 1398

#Unit 4. Cell Communication and Cell Signaling

Which of the following properties is (are) characteristic of a benign tumor?

a. well differentiated              b. localized to tissue of origin             c. metastatic               

d. promotes angiogenesis        e. surrounded by a fibrous capsule

TLS Online TPP Program

#Question id: 1399

#Unit 4. Cell Communication and Cell Signaling

Loss-of-function mutations in which of the following genes typifies colorectal carcinomas?

a. myc              b. K-ras                       c. p53              d. APC

TLS Online TPP Program

#Question id: 1400

#Unit 4. Cell Communication and Cell Signaling

Which property is shared by malignant tumor cells and transformed cells in culture?

a. reduced growth factor requirement                        b. attachment-dependent growth

c. loss of actin microfilaments                                    d. altered morphology

TLS Online TPP Program

#Question id: 1401

#Unit 4. Cell Communication and Cell Signaling

Which of the following are proto-oncogenes?

a. fos               b. myc             c. p53              d. ras               e. Rb

TLS Online TPP Program

#Question id: 1402

#Unit 4. Cell Communication and Cell Signaling

Which of the following oncoproteins possess(es) protein kinase activity?

TLS Online TPP Program

#Question id: 1403

#Unit 4. Cell Communication and Cell Signaling

Tumor-suppressor genes encode proteins with which of the following functions?

a. growth-promoting               b. growth-arresting                  c. pro-apoptotic

d. anti-apoptotic                      e. DNA repair