TLS Online TPP Program

#Question id: 4350


Portions of the DNA sequences of normal and mutant b-globin genes are shown. The most plausible explanation for why the indicated mutation (changing an A to a G) results in the disease b-thalassemia is that the mutation

#Unit 3. Fundamental Processes
  1. changes the amino acid specified by the codon of which the altered base is part

  2. generates a recognition site for a restriction enzyme, so the gene is cut in two

  3. creates a new splice site, so that a portion of the intron is not removed

  4. results in an increase in the transcription of the b-globin gene

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TLS Online TPP Program

#Question id: 4530

#Unit 3. Fundamental Processes

A protein complex engaged in the pairing of homologous chromosomes during cell division has also been implicated in stabilizing certain enhancer–promoter loops.

TLS Online TPP Program

#Question id: 4531

#Unit 3. Fundamental Processes

Specific elements called insulators control the actions of activators. When placed between an enhancer and a promoter,

TLS Online TPP Program

#Question id: 4532

#Unit 3. Fundamental Processes

Locus control region, or LCR,

TLS Online TPP Program

#Question id: 4533

#Unit 3. Fundamental Processes

When multiple activators work together, they often do so synergistically. That is, the effect of

TLS Online TPP Program

#Question id: 4534

#Unit 3. Fundamental Processes

The yeast Saccharomyces cerevisiae divides by budding: instead of dividing to produce two identical daughter cells, the so-called mother cell buds to produce a daughter cell, The HO gene is expressed only in mother cells and only at a certain point in the cell cycle,

1. SBF

I- Which is active only during the G1-S transition of the cell cycle.

2. SWI5

II-Which acts only in the mother cell.

III- Recruit nucleosome modifiers

TLS Online TPP Program

#Question id: 4535

#Unit 3. Fundamental Processes

The activators bind—and the enhanceosome forms—in a highly cooperative manner, ensuring that all three activators must be present. The following are three ways the regulators might be binding cooperatively:

I- Through direct protein–protein interactions between them

II- By changes in the DNA caused by binding of one protein helping binding of another;

III- By the fact that the activators all interact simultaneously with the coactivator.