TLS Online TPP Program

#Question id: 4350


Portions of the DNA sequences of normal and mutant b-globin genes are shown. The most plausible explanation for why the indicated mutation (changing an A to a G) results in the disease b-thalassemia is that the mutation

#Unit 3. Fundamental Processes
  1. changes the amino acid specified by the codon of which the altered base is part

  2. generates a recognition site for a restriction enzyme, so the gene is cut in two

  3. creates a new splice site, so that a portion of the intron is not removed

  4. results in an increase in the transcription of the b-globin gene

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TLS Online TPP Program

#Question id: 4078

#Unit 3. Fundamental Processes

Which of the following is (are) required for splicing to occur?

a. two transesterification reactions

b. intact, naturally occurring introns

c. formation of a lariat like structure

d. a branch-point G residue

TLS Online TPP Program

#Question id: 4079

#Unit 3. Fundamental Processes

What is the evidence that pre-mRNAs are not synthesized unless machinery for processing is properly positioned?

TLS Online TPP Program

#Question id: 4080

#Unit 3. Fundamental Processes

How the location of exons and introns within a gene are determined?

TLS Online TPP Program

#Question id: 4081

#Unit 3. Fundamental Processes

Which of the following regulatory scenarios of cell-type-specific expression of fibronectin isoforms in humans is (are) consistent with information on known splicing factors?

a. A Tra-like splicing factor expressed in fibroblasts is required for inclusion of EIIIA and EIIIB exons.

b. An Sxl-like splicing factor is required in hepatocytes for exclusion of EIIIA and EIIIB exons.

c. A Tra-2-like factor enhances binding of the cleavage/polyadenylation complex in fibroblasts.

d. A Dsx-like protein is required to inhibit transcription of the fibronectin gene.

TLS Online TPP Program

#Question id: 4082

#Unit 3. Fundamental Processes

Which of the following is (are) not involved in alternative splicing in eukaryotes?

TLS Online TPP Program

#Question id: 4083

#Unit 3. Fundamental Processes

Differential splicing of the Ca2+-activated K+ channel gene in ciliated neurons results in

a. hair cells with different response frequencies.

b. different channel isoforms.

c. channels that open at different calcium concentrations.

d. different channel mRNAs expressed in different cells.