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TLS Online TPP Program

#Question id: 4489

HSP70 gene from Drosophila. This gene, activated by heat shock, is controlled by two activators GAGA binding factor and HSF,In response to heat shock, HSF binds to specific sites at the promoter and recruits a kinase, P-TEFb (positive transcription elongation factor). What is the proper mechanism of pausing and release of Pol II ?

#Unit 3. Fundamental Processes

  1. Second phosphorylation on Serine5 is achieved through recruitment of the kinase P-TEFb

  2. P-TEFb is part of a super elongation complex, which releases paused Pol II from the proximal promoter.

  3. A strong acidic activator like Gal4 is able to recruit PTEFb/SEC along with the rest of the machinery

  4. B and C Only

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TLS Online TPP Program

#Question id: 12493

#Unit 8. Inheritance Biology

Cystic fibrosis shows autosomal recessive inheritance with an incidence of 1 in 2500. The unaffected brother of an affected girl is referred for genetic counseling. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?
TLS Online TPP Program

#Question id: 12494

#Unit 8. Inheritance Biology

Hunter syndrome is a rare form of mucopolysacchararidosis that differs from all other forms in that it shows X-linked recessive inheritance. A woman with two affected brothers is referred for genetic counselling. Which of the following is correct?
TLS Online TPP Program

#Question id: 12495

#Unit 8. Inheritance Biology

Haemophilia A is a severe coagulation disorder that shows X-linked recessive inheritance. Red-green colour blindness also shows X-linked recessive inheritance. A man with both haemophilia A and colour blindness is referred for genetic counseling. Assume that his partner is not a carrier of either of these conditions. Which of the following is correct?
TLS Online TPP Program

#Question id: 12496

#Unit 8. Inheritance Biology

A woman who has two brothers and a maternal uncle (her mother's brother) with non-specific X-linked mental retardation is referred for genetic counselling. There are no diagnostic tests available to help determine whether or not she is a carrier. Which of the following is correct?
TLS Online TPP Program

#Question id: 12497

#Unit 8. Inheritance Biology

In this pedigree A and B represent alleles at a marker locus closely linked to the disease locus. Affected individuals are shown as shaded. The disease status in III 1 is unknown. Which of the following is correct?
TLS Online TPP Program

#Question id: 12498

#Unit 8. Inheritance Biology

In this pedigree II 1 is affected with an autosomal recessive disorder. The disease status for II 2 and II 3 is unknown. A and B represent alleles at a locus which is tightly linked to the disease locus with recombination fraction of 0. On the basis of the linked marker genotypes II 2 can be told that: