TLS Online TPP Program

#Question id: 4489


HSP70 gene from Drosophila. This gene, activated by heat shock, is controlled by two activators GAGA binding factor and HSF,In response to heat shock, HSF binds to specific sites at the promoter and recruits a kinase, P-TEFb (positive transcription elongation factor). What is the proper mechanism of pausing and release of Pol II ?

#Unit 3. Fundamental Processes
  1. Second phosphorylation on Serine5 is achieved through recruitment of the kinase P-TEFb

  2. P-TEFb is part of a super elongation complex, which releases paused Pol II from the proximal promoter.

  3. A strong acidic activator like Gal4 is able to recruit PTEFb/SEC along with the rest of the machinery

  4. B and C Only