Practice Questions

TLS Online TPP Program

#Question id: 31335

The following statements are made with reference to SNARE proteins & membrane fusion reactions in vesicle transport. Which of the following statement is incorrect?

#Unit 2. Cellular Organization

The v-SNARE, known as vesicle-associated membrane protein, is incorporated into secretory vesicles as they bud from the trans-Golgi network.
The t-SNAREs are syntaxin, a lipid anchored protein and SNAP-25, an integral membrane protein in the plasma membrane.
The cytosolic region in each of these three SNARE proteins contains a repeating heptad sequence that allows four α helices to coil around one another to form a four-helix bundle.
After fusion is completed, the SNARE complex is disassembled in an ATP-dependent reaction mediated by other cytosolic proteins.

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TLS Online TPP Program

#Question id: 28918

#Unit 4. Cell Communication and Cell Signaling

Which of the following statements is correct about Sonic hedgehog?

TLS Online TPP Program

#Question id: 28919

#Unit 4. Cell Communication and Cell Signaling

Given some statements about Hedgehog processing and secretion;

a) autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion

b) autoproteolytic activity that cleaves off the N-terminus to reveal a signal sequence that marks the protein for secretion

c) Secretion requires the addition of cholesterol and palmitic acid

d) Secretion requires the modification of Hh by Glycosylation

Which of the following is correct prediction about processing and secretion of Hh?

TLS Online TPP Program

#Question id: 28920

#Unit 4. Cell Communication and Cell Signaling

Which of the following is a correct prediction about processing and secretion of Hedgehog protein ?

a) the freed N-terminal is not involved in signaling and is often degraded

b) the freed C-terminal is not involved in signaling and is often degraded

c) the N-terminal becomes the active Hedgehog protein intended for secretion

d) the C-terminal becomes the active Hedgehog protein intended for secretion

TLS Online TPP Program

#Question id: 28921

#Unit 4. Cell Communication and Cell Signaling

Which of the following modification is required for the Secretion of Hh protein?

TLS Online TPP Program

#Question id: 28922

#Unit 4. Cell Communication and Cell Signaling

Hedgehog binding receptor is called___

TLS Online TPP Program

#Question id: 28923

#Unit 4. Cell Communication and Cell Signaling

Which of the following are seven TM α helices and is a member of the GPCR Superfamily?

b) Smoothened (Smo)

c) Patched (Ptc)

d) Frizzled (Fz)