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TLS Online TPP Program

#Question id: 31376

In S. cerevisiae, DNA replication is tightly controlled, and DNA should replicate once per cell cycle. Choose the INCORRECT statement regarding why the cells do not re-replicate their DNA in the S-phase?

#Unit 2. Cellular Organization
  1. Because S phase CDKs phosphorylate several components of the MCM helicase-loading machinery.
  2. Because phosphorylation leads to export of Cdt1 from the nucleus, and degradation of Cdc6 by the SCF ubiquitin-protein ligase in yeast.
  3. Because Cdt1 which helps in the recruitment of MCM proteins in the Gl phase is inactivated by geminin in the S-phase of the cell cycle.
  4. Because MCM helicases are loaded onto DNA to form pre-RCs only when they are phosphorylated.
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TLS Online TPP Program

#Question id: 27954

#Unit 1. Molecules and their Interaction Relevant to Biology

Some of the statement is given regarding the Pyruvate kinase 
a. Pyruvate kinase is activated  by ATP, acetyl-CoA, long-chain fatty acids 
b. Pyruvate kinase is allosterically inhibited by ATP, acetyl-CoA, long-chain fatty acids
c. Accumulation of alanine allosterically inhibits pyruvate kinase M in muscles, slowing the production of pyruvate by glycolysis
d. Accumulation of alanine activate pyruvate kinase M in muscles, increases the production of pyruvate by glycolysis

Which of the following is incorrect
TLS Online TPP Program

#Question id: 2983

#Unit 2. Cellular Organization

Cell cycle is regulated by master regulators (cyclin and CDKs). In vertebrates, G1 CDK activity rises during G1 and is stimulated by the presence of growth factors. When signaling from growth factors is sustained, the resulting cyclin D–CDK4/6 complexes begin phosphorylating Rb, releasing some E2F, which stimulates transcription of the genes encoding cyclin E, CDK2, and E2F itself. In a particular cell type there is a mutation in Rb such that it cannot be phosphorylated. What will be the correct expression pattern of cyclin E in these cells after mitotic stimulation?
TLS Online TPP Program

#Question id: 743

#Unit 1. Molecules and their Interaction Relevant to Biology

Glycophorin, an integral membrane protein, has a single transmembrane alpha helix. Which of the following idealized hydropathy plots most likely represents the transmembrane nature of glycophorin?
TLS Online TPP Program

#Question id: 19235

#Unit 12. Applied Biology

A way by which specific foreign protein can be introduced into the chloroplast or mitochondrion.
TLS Online TPP Program

#Question id: 1788

#Unit 4. Cell Communication and Cell Signaling

What is the major factor regulating the adaptive immune response?