TLS Online TPP Program

#Question id: 7103


Patterning of the Xenopus mesoderm along the dorso-ventral axis involves an antagonistic relationship between chordin and BMP-4. Is there an analogy here to dorso-ventral patterning in the Drosophila embryo?

#Unit 5. Developmental Biology
  1. Yes, the Drosophila homolog of BMP-4, Decapentaplegic (Dpp), is antagonized by the Drosophila homolog of chordin, short gastrulation (Sog), in patterning of the dorso-ventral axis.
  2. Yes, Drosophila also uses BMP-4 to specify ventral fates and chordin to specify dorsal fates.
  3. Yes, the Drosophila Dorsal protein is identical to the vertebrate BMP-4 protein, and specifies the ventral region of the embryo.
  4. No. the closest analogy from Drosophila would be the antagonism between Hunchback and Nanos, but neither of those are signalling molecules, and they act to pattern the antero-posterior axis.