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TLS Online TPP Program

#Question id: 799

The two cleavage reactions required to generate the miRNA from these primary transcripts are mediated by two distinct RNases. A characteristic of both these enzymes is that they recognize and cleave RNAs on the basis of the structure of their substrates rather than their specific sequence. Which of the following statement is INCORRECT regarding the cleavage reactions that produces a mature RNA?

#Unit 1. Molecules and their Interaction Relevant to Biology

  1. Drosha resides in the cell’s nucleus, and the Drosha-catalyzed cleavage event occurs in that cellular compartment that generates a pre-miRNA which is ~65–70 nucleotides long.

  2. The pre-miRNA liberated by Drosha is exported to the cytoplasm, where the second RNA cleavage reaction, performed by Dicer, takes place which cleaves pre-miRNA 22 nucleotides from its ends.

  3. For processing by Drosha, ssRNA lacking significant secondary structure, is needed flanking each side (5’ and 3’) of the stem-loop. It is the ssRNA–dsRNA junctions that are in responsible for determining the cleavage specificity of Drosha.

  4. The RNase II family enzymes are specific for dsRNA and cleave it in a manner that leaves a 2-nucleotide overhang on the 3’ ends of the dsRNA product. This 3’ overhang is important for recognition of that RNA molecule by the next enzyme in the pathway, Dicer.

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TLS Online TPP Program

#Question id: 4237

#Unit 3. Fundamental Processes

A part of an mRNA molecule with the following sequence is being read by a ribosome: 5′-CCGACG- 3′ (mRNA). The following charged transfer RNA molecules (with their anticodons shown in the 3′ to 5′ direction) are available. Two of them can correctly match the mRNA so that a dipeptide can form. Which of the following dipeptides will form from this mRNA?
TLS Online TPP Program

#Question id: 4272

#Unit 3. Fundamental Processes

There are two classes of release factors for translation termination. Choose correct statements

A. Class I release factors recognize the stop codons and trigger hydrolysis of the peptide chain from the tRNA in the P-site.

B. Prokaryotes have two class I release factors called RF1 and RF2. RF1 recognizes the stop codon UGA, UAA and RF2 recognizes the stop codon UAG and UAA.

C. In eukaryotic cells, there is a single class I release factor called eRF1 that recognizes all three stop codons.

D. Class II release factors stimulate the dissociation of the ribosome after release of the polypeptide chain.
TLS Online TPP Program

#Question id: 9595

#Unit 6. System Physiology – Plant

The process is that the absorbed photon causes an electron rearrangement in the reaction centre chlorophyll, followed by an electron transfer process in which part of the energy in the photon is captured in the form of
TLS Online TPP Program

#Question id: 28951

#Unit 7. System Physiology – Animal

Principal signaling pathway activated by the growth hormone, that is___
TLS Online TPP Program

#Question id: 5343

#Unit 8. Inheritance Biology

 Dosage Compensation in case of mammal is result in