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TLS Online TPP Program

#Question id: 11458

A person able to hear only low-frequency sounds would probably have which of the following structural problems in the ear?

#Unit 7. System Physiology – Animal
  1. The tympanum is damaged because of chronic ear infections.
  2. The basilar membrane is stiffened along its entire length.
  3. The ear ossicles are abnormally thickened.
  4. There is a loss of hair cell function in the area closest to the oval window.
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TLS Online TPP Program

#Question id: 4267

#Unit 3. Fundamental Processes

The 3D structure of the complete Escherichia coli ribosome with bound mRNA and tRNAs revealed that the very amino terminus of one protein (L27) does reach into the active site. This finding suggested a role for this protein in catalysis. To test this possibility, the nine amino acids at the L27 amino terminus that were in close proximity to the active site were eliminated by mutation. The following possible outcomes were found to be correct as

A. The resulting cells produced ribosomes with reduced but detectable peptidyl transferase activity

B. Region of the L27 protein contributes to peptidyl transferase activity

C. The mutant ribosomes, didn’t synthesised wildtype levels of cells

D. Vast majority of this increase in peptide bond formation is retained, even without the presence of L27 in the active site

E. The most likely role for L27 is to correctly position one or more of the RNA components of the active site
TLS Online TPP Program

#Question id: 11972

#Unit 7. System Physiology – Animal

The active ingredient orlistat acts to decrease the amount of fat that is absorbed by attaching to enzymes that digest fat. Which of the following are potential targets of orlistat?
TLS Online TPP Program

#Question id: 1954

#Unit 4. Cell Communication and Cell Signaling

What is the single best description of type 1 diabetes?
TLS Online TPP Program

#Question id: 17659

#Unit 13. Methods in Biology

During your study of the gene for an enzyme you have isolated an amber mutation in the middle of the gene which produces a truncated form of the enzyme. By placing a +1 frameshift mutation a short distance before the amber mutation and a –1 frameshift mutation a short distance after the amber mutation you create a triple mutant that restores expression of a functional, full-length enzyme. 
a) +1 frameshift puts the amber mutation out of frame so that it is no longer read as a stop.
b) -1 frameshift is inserted after the amber so that no longer read as a stop.
c)  -1 frameshift is inserted after the amber to restore the frame of the end of the protein.
d) +1 frameshift puts the amber mutation out of frame so that it restore the frame of the end of the protein.
Which of the following is the correct prediction about the frame shift mutation?
TLS Online TPP Program

#Question id: 11666

#Unit 7. System Physiology – Animal

The osmoregulatory process called secretion refers to the ________.