Choose correct statements about ‘Protein Disulfide Isomerase’ in protein folding

A. Oxidized PDI catalyzes the rearrangement of a polypeptide’s non-native disulfide bonds via disulfide interchange reactions to yield native disulfide bonds.

B. Reduced PDI catalyzes the initial formation of a polypeptide’s disulfide bonds through the formation of a mixed disulfide.

C. Protein disulfide isomerase contains the conserved active site motif of Cys-Xaa-Xaa-Cys found in thioredoxin and shares a similar role to the Dsb family of proteins found in E. coli.

D. Under more reducing conditions with thiols in the active site the enzyme reshuffles disulfides (isomerase) in target proteins.

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#Question id: 27095

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correct regarding the Type I β turn positions  Ramachandran plot

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#Question id: 27096

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is incorrect regarding the Type II β turns

TLS Online TPP Program

#Question id: 27097

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correct regarding the β turns

(1) In Type I β turn i+1 lies in RHH region while i+2 lies near BS region

(2) In Type II β turn i+1 lies in BS while i+2 lies in below LHH

(3) In Type I’ β i+1and i+2 in near LHH which virtually not allowed region for most of amino acid except Gly

(4) In Type II’ β i+2 lies at 00 psi and i+1 in lower right region both i+2 and   i+1  must be Gly

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#Question id: 27098

#Unit 1. Molecules and their Interaction Relevant to Biology

On what positions Beta turns are characterised

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#Question id: 27099

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statement is wrong regarding the α -Turn

TLS Online TPP Program

#Question id: 27100

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statement is correct regarding the α -Turn and β turns

(1)In α - Turn H-bond is seen between i and i + 4 (First and Fifth residue)

(2) In α Turn conformation is based on i + 1 , i + 2 and i + 3 on the basis of this, they are classified

(3)In β turns H-bond is seen between i and i + 4 (First and Fifth residue)

(4) In β turns  conformation of i + 1 and i + 2 are crucial and on the basis of this, they are classified