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TLS Online TPP Program

#Question id: 12186

In 2001, the Nobel Prize in Physiology or Medicine was awarded to three cell cycle scientists. Paul Nurse was recognized for his studies with the fission yeast S. pombe, in particular for the discovery and characterization of the wee1+ gene. What did the characterization of the wee1+ gene tell us about cell cycle control?

#Unit 2. Cellular Organization
  1. The dual-specificity protein kinase Wee1 phosphorylates CDKs on the activatory tyrosine 15.
  2. Yeast cells with a defective wee1+ gene activate S phase CDKs prematurely and hence experience premature entry into DNA replication. 
  3. Fission yeast cells carrying a CDK1 mutation in which the tyrosine 15 residue is replaced by phenylalanine (which is structurally similar to tyrosine but cannot be phosphorylated) show the premature mitotic CDK activation and entry into mitosis.
  4. The dual-specificity protein phosphatase Wee1 dephosphorylates CDKs on the inhibitory tyrosine 15.

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TLS Online TPP Program

#Question id: 11519

#Unit 2. Cellular Organization

The mechanism postulated for P-type ATPases takes into account the large conformational changes and the phosphorylation dephosphorylation of the critical:
TLS Online TPP Program

#Question id: 34159

#Unit 7. System Physiology – Animal

Mice lacking dopamine β-hydroxylase are cold-intolerant but have high basal metabolic rate because:
TLS Online TPP Program

#Question id: 2542

#Unit 2. Cellular Organization

Which of the following organelles produces and modifies polysaccharides that will be secreted?
TLS Online TPP Program

#Question id: 20986

#Unit 12. Applied Biology

In consistent fashion the btex hydrocarbon decay is linked with __________as the terminal electron acceptor.
TLS Online TPP Program

#Question id: 5273

#Unit 8. Inheritance Biology

Replica plating