A brick 2" thick is placed againsta wheel to act for a stop. The horizontal distance of the face of the brick from the point where the wheel touches the ground is 6". The radius of the wheel in inches is

TLS Online TPP Program

#Question id: 30105

#Unit 1. Structure and Function of Biomolecules

Methotrexate is an inhibitor of dihydrofolate reductase. Administration of methotrexate would inhibit:

1. de novo synthesis of UMP.

2. conversion of dUMP to dTMP.

3. conversion of IMP to GMP.

4. de novo synthesis of IMP

TLS Online TPP Program

#Question id: 30106

#Unit 1. Structure and Function of Biomolecules

If a cell has an adequate supply of adenine nucleotides but requires more guanine nucleotides for protein synthesis:

1. Glutamine-PRPP amidotransferase will not be fully inhibited.

2. AMP will be a feedback inhibitor of the condensation of IMP with aspartate.

3. ATP will stimulate the production of GMP from IMP.

4. ATP will inhibit nucleoside diphosphate reductase.

TLS Online TPP Program

#Question id: 30107

#Unit 1. Structure and Function of Biomolecules

Major controls of de novo AMP synthesis include:

1. allosteric inhibition by GMP.

2. allosteric inhibition by AMP.

3. availability of PRPP.

4. stimulation by GTP.

TLS Online TPP Program

#Question id: 30108

#Unit 1. Structure and Function of Biomolecules

Aspartate plays a role in all of the following EXCEPT:

TLS Online TPP Program

#Question id: 30109

#Unit 1. Structure and Function of Biomolecules

Allopurinol is an inhibitor of xanthine oxidase. Administration of allopurinol to a patient with gout and normal HG-PRT levels would be expected to lead to all of the following EXCEPT:

TLS Online TPP Program

#Question id: 30110

#Unit 1. Structure and Function of Biomolecules

The ribose phosphate group of purine nucleotide is taken from which compound?