Refer to the following experiment, which is designed to test the co evolutionary relationships among an unpalatable butterfly (the  monarch),  a  palatable  butterfly  (the  viceroy),  and  a  butterfly  predator  (the  jay).  Monarch butterflies are reared on three diets: milkweed (their natural food), cabbage, and cabbage treated with an extract from milkweed leaves. Viceroy butterflies, mimics of monarchs, also are reared on three diets: willows (their natural food), cabbage, and cabbage treated with an extract from milkweed leaves. In trial 1 of the first experiment, adult butterflies reared on a particular diet are presented one at a  time  at  1-hour  intervals  to  jays  and  the  jays  are  allowed  to  feed.  Each jay is  fed  until  it refuses to eat the butterfly presented, but no more than 12 butterflies are presented to a jay during a particular test. Five birds are used for each test; therefore, up to 60 butterflies can be consumed for each diet test. The observer records the actual number of butterflies  eaten. In trial 2, the experiment is repeated 2 weeks later. In the second experiment, the butterflies are reared on the same diets as in experiment 1. However, when they are offered to jays, some jays receive a monarch  reared  on  milkweed  before  being  offered  the  butterflies  reared  on  the  experimental  diets;  the  other  group  of jays is  first given a viceroy reared on willow before being  offered the butterflies reared on the experimental diets. The initial butterfly offered is included in the total number eaten, but no more than 12 butterflies are presented to each jay.

The data in the table indicate which of the following?

#Question id: 890

#Unit 1. Molecules and their Interaction Relevant to Biology

Some of the misfolded protein or defective Protein causes disease as follows;

#Question id: 891

#Unit 1. Molecules and their Interaction Relevant to Biology

The folding pathways of some proteins require two enzymes that catalyze isomerization reactions such as,

a) Peptide prolyl isomerase (PPI)  catalyzes the elimination of folding intermediates with inappropriate disulfide cross-links

b) Protein disulfide isomerase (PDI) enzyme that catalyzes the interchange, or shuffling, of disulfide bonds until the bonds of the native conformation are formed

c) Peptide prolyl cis-trans isomerase (PPI) catalyzes the interconversion of the cis and trans isomers of Proline residue peptide bonds

d) Peptide prolyl isomerase (PPI) can be a fast step in the folding of proteins that contain some Pro peptide bonds in the cis conformation

Which of the following combinations is correct about protein folding pathways?

#Question id: 892

#Unit 1. Molecules and their Interaction Relevant to Biology

Assisted protein folding is mediated by a group of proteins known as chaperons, which of the following statements is incorrectly reperesents chaperon activity;

#Question id: 893

#Unit 1. Molecules and their Interaction Relevant to Biology

Like E.coli eukaryotic cells also contain chaperonin, which of the following in eukaryotic chapronin is incorrect?

#Question id: 894

#Unit 1. Molecules and their Interaction Relevant to Biology

When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)

a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway

b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy

c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations

d)  UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions

Which of the following statements would be incorrect?

#Question id: 895

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is van’t Hoff plot equation?