Practice Questions

TLS Online TPP Program

#Question id: 13160

According to the Switching mechanism, monomeric G proteins exist in two states. Match the following states (Column I) with correct mechanism (Column II).

Column I

Column II

A. “ON” state

i. switch I and switch II, are bound to the terminal γ phosphate of GTP through interactions with the backbone amide groups of conserved threonine and glycine residues.

B. “OFF” state

ii. GTPase-activating proteins

iii. guanine nucleotide exchange factor

iv. Due to the removal of the γ phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to relax into a different conformation

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Column I	Column II
A. “ON” state	i. switch I and switch II, are bound to the terminal γ phosphate of GTP through interactions with the backbone amide groups of conserved threonine and glycine residues.
B. “OFF” state	ii. GTPase-activating proteins
	iii. guanine nucleotide exchange factor
	iv. Due to the removal of the γ phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to relax into a different conformation