According to the Switching mechanism, monomeric G proteins exist in two states. Match the following states (Column I) with correct mechanism (Column II).

Column I	Column II
A. “ON” state	i. switch I and switch II, are bound to the terminal γ phosphate of GTP through interactions with the backbone amide groups of conserved threonine and glycine residues.
B. “OFF” state	ii. GTPase-activating proteins
	iii. guanine nucleotide exchange factor
	iv. Due to the removal of the γ phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to relax into a different conformation

TLS Online TPP Program

#Question id: 26444

#Unit 3. Fundamental Processes

global genome repair (GG-NER) depending on proteins

TLS Online TPP Program

#Question id: 26445

#Unit 3. Fundamental Processes

In transcription-coupled repair (TC-NER) TFIIH, itself a large complex, which includes the products of two XP genes, XPB and XPD, which of the following is correctly representing the function of XPB and XPD

TLS Online TPP Program

#Question id: 26446

#Unit 3. Fundamental Processes

Which of the following is a universal marker for double strand breaks

TLS Online TPP Program

#Question id: 26447

#Unit 3. Fundamental Processes

Which polymerases are template-dependent, they incorporate nucleotides in a manner that is independent of base pairing

TLS Online TPP Program

#Question id: 26448

#Unit 3. Fundamental Processes

Choose the correct statement regarding DNA photolyase 

a.MTHF polyglu absorb blue light photon of 300-500 nm

b.And the MTHF polyglu radicalize FADH cofactor

c.And this FADH cofactor donate single electron to CBD 

d.And this FADH cofactor donate many electron to CBD

TLS Online TPP Program

#Question id: 26449

#Unit 3. Fundamental Processes

Ability of core and holoenzyme to transcribe DNAs differs, so choose which of the following is correct

a.With  subunit, the holoenzyme worked equally well on both intact as well as nicked types of DNA

b.With  subunit, the holoenzyme worked unequally on both intact as well as nicked types of DNA

c.Core subunit α2ββσ can not perform polymerization on to the intact DNA while perform some of the activity on to the nicked DNA

d.Core subunit α2ββσ can not perform polymerization on to the intact DNA AS WELL AS  to the nicked DNA