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TLS Online TPP Program

#Question id: 887

Polypeptides fold rapidly by a stepwise process, how does the polypeptide chain arrive at its native conformation?

#Part-B Specialized Branches in Biotechnology

  1. proteins appear to fold in a hierarchical manner, with small local elements of structure forming and then to yield larger elements, which coalesce with other such elements to form yet larger elements and converted into its native conformation

  2. A protein-folding pathway has been highly successful in predicting the three-dimensional structure of small proteins from their amino acid sequence atleast 156 amino acid residue that have acquired their final structure

  3. Vander waal interaction play a significant role throughout the process, as the aggregation of nonpolar amino acid side chains provides an entropic stabilization to intermediates and, eventually, to the final folded structure

  4. The native conformation of the protein folding by stepwise manner such as unfolded→transition state→molten globule→folded conformation by decreasing the free energy

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TLS Online TPP Program

#Question id: 18779

#Part-A Aptitude & General Biotechnology

Flow-cytometric analysis for the detection and measurement of subpopulations of leukocytes, including those of leukaemia, is usually performed using monoclonal antibodies. Why is this the case?
Choose whether each of the following statements is true 
a) Indirect immunofluorescence is a more sensitive technique than direct immunofluorescence
b) Most antigens induce a polyclonal response. 
c) For precipitation to occur, both antigen and antibody must be multivalent.
d) ELISA tests using chemiluminescence are more sensitive than chromogenic ones and precipitation tests are more sensitive than agglutination tests
TLS Online TPP Program

#Question id: 18780

#Part-A Aptitude & General Biotechnology

Which of the following does not participate in the formation of antigen-antibody complexes?
TLS Online TPP Program

#Question id: 18781

#Part-A Aptitude & General Biotechnology

In which of the following case a large lattice is formed?
TLS Online TPP Program

#Question id: 18782

#Part-A Aptitude & General Biotechnology

The concentration of a small amount antibodies 2 μg antibody/ml can be detected
TLS Online TPP Program

#Question id: 18783

#Part-A Aptitude & General Biotechnology

Sensitivity of various immunoassays are given match them correctly

Assay

Sensitivity∗ (g antibody/ml)

a) Mancini radial immunodiffusion

i) 2

b) Ouchterlony double immunodiffusion

ii) 20–200

c) Immunoelectrophoresis

iii) 20–200

d) Rocket electrophoresis

iv) 10–50

TLS Online TPP Program

#Question id: 18784

#Part-A Aptitude & General Biotechnology

Which of the following is the sine qua non (without which, nothing) of the modern immunologist’s toolbox.